快樂小藥師 Im pharmacist nichts glücklich

CLINICAL CONTEXT

Lorcaserin is a serotonin 2C receptor agonist indicated for chronic weight management in adults when used in conjunction with a caloric restriction diet and increased physical activity. The effect of lorcaserin on cardiovascular morbidity and mortality has not been established.

INTRODUCTION

There is increasing recognition of the similarities in the etiology of constipation predominant irritable bowel syndrome (IBS-C) and chronic constipation (CC), and a more inclusive terminology is emerging of constipation-related functional gastrointestinal (GI) disorders, which embraces both conditions. This is partly driven by the increasing appreciation that IBS-C and CC share a number of common underlying causes and presenting symptoms, which are described below.

Aflibercept (Zaltrap, Regeneron/Sanofi) has been approved by the US Food and Drug Administration (FDA) for use in the treatment of metastatic colorectal cancer.

Late today the FDAapproved a patented synthetic ethyl eicosapentaenoic acid (EPA),icosapent ethyl (Vascepa, formerly AMR101, Amarin) [1], for the treatment of hypertriglyceridemia. It should now become the market's second omega-3 polyunsaturated fatty acid (PUFA) preparation available only by prescription.

The US Food and Drug Administration has approved prednisone delayed-release tablets (Rayos, Horizon Pharma) at the 1-, 2-, and 5-mg doses for rheumatoid arthritis (RA).

The European Medicines Agency has for the first time recommended approval of a gene therapy, for the treatment of lipoprotein lipase (LPL) deficiency. The agency's Committee for Medicinal Products for Human Use (CHMP) recommended marketing authorization under "exceptional circumstances" for alipogene tiparvovec (Glybera, uniQure). The drug was designated an "orphan medicine" on March 8, 2004, and is recommended for use in a restricted group of adults with familial LPL deficiency who have severe or multiple pancreatitis attacks despite dietary fat restrictions.

Based on postmarketing surveillance data, the US Food and Drug Administration is updating healthcare professionals on the risk for seizures in patients with multiple sclerosis (MS) who begin treatment with dalfampridine (Ampyra, Acorda Therapeutics, Inc).

The US Food and Drug Administration (FDA) today approved aclidinium bromide 400 μg (Tudorza Pressair, Forest Laboratories) for maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the agency announced today.

美國食品藥物管理局〔2012-06-08〕批准了 Perjeta （Pertuzumab）用於治療 HER2 陽性的晚期（轉移性）乳腺癌患者。

A new drug that targets HER2-positive breast cancer, pertuzumab (Perjeta, Genentech/Roche), has been approved in the United States. About one quarter of all cases of breast cancer are HER2-positive.

The US Food and Drug Administration (FDA) approved a combination meningitis vaccine for infants and children ages 6 weeks through 18 months, the agency announced today.

因為網路分級的關係，本篇文章具有大量引起妳不舒服及可能改變妳身心狀態的圖片，請確定妳已經成年及心智成熟，否則請不要閱讀，謝謝

來自臺灣的文獻：合成的樟芝菌絲體中馬來酸衍生物是否可以抑制乳癌細胞增生

Lin WL; Lee YJ; Wang SM; Huang PY; Tseng TH
Department of Pathology, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo N. Road, Taichung 402, Taiwan.

News Author: Megan Brooks
CME Author: Désirée Lie, MD, MSEd

Question:

What are the liability risks for pharmacists when switching brand-name drugs to generics?

Avanafil (Stendra, Vivus), a new drug to treat erectile dysfunction (ED), was approved today by the US Food and Drug Administration (FDA).

Physicians must not prescribe antihypertensive drugs containing aliskiren (Tekturna, Novartis Pharmaceuticals) in combination with angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) for patients with diabetes, the US Food and Drug Administration (FDA) announced today.

Daptomycin (Cubicin, Novartis) achieves clinical cure rates of 72% in sepsis caused byStaphylococcus aureus and of 85% in sepsis caused byStaphylococcus epidermidis. High-dose daptomycin is also safe and tolerable, according to posters presented here at the 22nd European Congress of Clinical Microbiology and Infectious Diseases.

仿單資訊：http://www.cubicin.com/pdf/PrescribingInformation.pdf

Question:

I have started receiving prescriptions for tenofovir disoproxil fumarate/emtricitabine (Truvada®) for preexposure prophylaxis against HIV infection. What specific considerations or guidance are available to safely evaluate and monitor these patients?

Response from Kim Scarsi, MS, PharmD
Research Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Ismail Cinel, MD, PhD; Steven M. Opal, MD

Abstract and Introduction

Clin Transplant.  2012; 26(1):57-66 (ISSN: 1399-0012)