- Jul 08 Thu 2010 08:24
- Jul 02 Fri 2010 07:20
This review describes the current status of antiplatelet therapy in preven- tion of cardiovascular events of an atherothrombotic nature. The efficacy of aspirin clearly outweighs bleeding risk in secondary prevention, with the re- levant exception of patients with peripheral arterial disease (PAD). In trials of primary prevention, aspirin has a limited advantage, which is challenged by the risk of major bleeding. A typical example is primary prevention in type 2 diabetes mellitus, in which a number of trials and a recent meta-analysis have confirmed these limitations.
- Jun 30 Wed 2010 07:06
Dalbavancin, oritavancin and telavancin are semisynthetic lipoglycopep- tides that demonstrate promise for the treatment of patients with infections caused by multi-drug-resistant Gram-positive pathogens. Each of these agents contains a heptapeptide core, common to all glycopeptides, which enables them to inhibit transglycosylation and transpeptidation (cell wall synthesis). Modifications to the heptapeptide core result in different in vitro activities for the three semisynthetic lipoglycopeptides.
- Jun 29 Tue 2010 07:01
Anaerobic bacteria are the predominant indigenous flora of humans and, as a result, play an important role in infections, some of which are serious with a high mortality rate. These opportunistic pathogens are frequently missed in cultures of clinical samples because of shortcomings in collection and transport procedures as well as lack of isolation and susceptibility testing of anaerobes in many clinical microbiology laboratories. Correlation of clinical failures with known antibacterial resistance of anaerobic bacteria is seldom possible. Changes in resistance over time, and the discovery and characterization of resistance determinants in anaerobic bacteria, has in- creased recognition of problems in empirical treatment and has even resulted in changes in treatment guidelines. This review discusses the role of anaerobic bacteria in the normal flora of humans, their involvement in different mixed infections, developments in antibacterial resistance of the most frequent anaerobic pathogens and possible new treatment options.
- Jun 28 Mon 2010 06:58
Invasive candidiasis (IC) is an important infection in the intensive care unit (ICU) setting given its association with poor clinical outcomes. The epidemiology of IC is complex and, although incompletely elucidated, is characterized by considerable regional and temporal variability. Overall, there appears to be an increase in the incidence of IC and a change in dis- tribution of the causative Candida spp. Of particular concern is an increase in the proportion of episodes caused by Candida glabrata, which is associated with reduced susceptibility to azole antifungal agents.
- Jun 27 Sun 2010 07:44
The principal function of high-density lipoprotein (HDL) is to facilitate the reverse cholesterol transport (RCT) and inhibition of atheroma forma- tion. Epidemiological studies and interventional trials have suggested that HDL has cardioprotective properties.
- Jun 26 Sat 2010 09:56
- Jun 18 Fri 2010 07:08
- Jun 10 Thu 2010 07:17
- Jun 05 Sat 2010 07:50
- Jun 02 Wed 2010 01:22
- Jun 01 Tue 2010 07:37
- May 30 Sun 2010 07:28
Shannon A. Kavanaugh, Lisa A. White and Jill M. Kolesar
SHANNON A. KAVANAUGH, B.A., is student, School of Pharmacy, University of Wisconsin (UW), Madison. LISA A. WHITE, B.S., is student, School of Pharmacy, UW. JILL M. KOLESAR, PHARM.D., BCPS, FCCP, is Professor of Pharmacy, School of Pharmacy and Paul P. Carbone Comprehensive Cancer Center, UW