Individual Management of Drug extravasation~5

DRUG

GROUP

ASPIRATE

And instill

steroids001

‘SPREAD’ AND DILUTE

 

LOCALISE AND NEUTRALISE

SPECIFIC MANAGEMENT

ADDITIONAL

INFORMATION

Paclitaxel

5

Y

 

Y

Infiltrate the area with a mixture d of hydrocortisone and chlorpheniramine as 0.2ml ‘pin cushion’ subcutaneous injections. Follow by hyaluronidase a and then warm compressions g alternated with the application of topical antihistamine cream.4 In severe cases 1g of oral sodium cromoglycate should be administered as soon as possible after the injury and can be followed by 200mg four times a day for the next three days

 

Pentostatin

1

Y

Y

 

Infiltrate the site with hyaluronidase.a Apply heat and compression.2 g

 

Raltitrexed

2

Y

 

Y

Apply topical hydrocortisone and cover the area with an ice pack h for the next 4 hours. If the local reaction has then settled apply heat g for a further 24 to 48 hours. 2

Possibility of local inflammation. S/C hyaluronidase may facilitate dispersion of large volume extravasations in addition to the warm compressions

Streptozocin

5

Y

 

Y

Apply topical DMSO, every 2 hours at the extravasation site followed by topical hydrocortisone cream and a cold compress.1 h

Avoid contact with good skin. If blistering occurs, stop the DMSO and seek further advice. Sodium bicarbonate may have a role.

Surgical excision e is sometimes required to prevent serious damage

Teniposide

3

Y

 

Y

Give hydrocortisone via the venflon and sc hyrocortisone as 0.2 ml multiple injections around the circumference of the affected area, apply topical hydrocortisone and cover the area with an ice pack.2 h

 

Possibility of local inflammation or necrosis and/or pain. There are no specific antidotes for these drugs.

 

 

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