Ceredase® (alglucerase injection) is a modified form of the enzyme, β-glucocerebrosidase (β-Dglucosyl-N-acylsphingosine glucohydrolase, EC 188.8.131.52). Alglucerase is a monomeric glycoprotein of 497 amino acids withcarbohydrates making up approximately 6% of the molecule (Mr = 59,300 as determined by SDS-PAGE). The unmodified enzyme (β-glucocerebrosidase) also contains 497 amino acids and contains approximately 12% carbohydrate (Mr = 67,000). The carbohydrates on the unmodified enzyme consist of N-linked carbohydrate chains of the complex and high mannose type. Glucocerebrosidase and alglucerase catalyze the hydrolysis of the glycolipid, glucocerebroside, within the lysosomes of the reticuloendothelial system.
Cerezyme® (imiglucerase for injection) is an analogue of the human enzyme
ß-glucocerebrosidase, produced by recombinant DNA technology.
ß-Glucocerebrosidase (ß-D-glucosyl-N-acylsphingosine glucohydrolase, E.C. 184.108.40.206)
is a lysosomal glycoprotein enzyme which catalyzes the hydrolysis of the glycolipid
glucocerebroside to glucose and ceramide.
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indicated for long-term enzyme replacement therapy in patients with type 1 Gaucher disease.