Cream: Females ≥12 years: Reduce unwanted hair from face and adjacent areas under the chin
不過聽說他也有針劑：Treatment of meningoencephalitic stage of Trypanosoma brucei gambiense infection (sleeping sickness)，簡單的說，就是非洲睡眠症，在台灣算是孤兒藥吧
Unwanted facial hair (Females): Topical: Apply thin layer of cream to affected areas of face and adjacent chin twice daily, at least 8 hours apart.
Treatment of infections caused by Trypanosoma : I.V. infusion (orphan drug): 100 mg/kg/dose given every 6 hours (over at least 45 minutes) for 14 days.
Eflornithine exerts antitumor and antiprotozoal effects through specific, irreversible (“suicide”) inhibition of the enzyme ornithine decarboxylase (ODC). ODC is the rate-limiting enzyme in the biosynthesis of putrescine, spermine, and spermidine, the major polyamines in nucleated cells. Polyamines are necessary for the synthesis of DNA, RNA, and proteins and are, therefore, necessary for cell growth and differentiation. Although many microorganisms and higher plants are able to produce polyamines from alternate biochemical pathways, all mammalian cells depend on ornithine decarboxylase to produce polyamines. Eflornithine inhibits ODC and rapidly depletes animal cells of putrescine and spermidine; the concentration of spermine remains the same or may even increase. Rapidly dividing cells appear to be most susceptible to the effects of eflornithine. Topically, the inhibition of ODC in the skin leads to a decreased rate of hair growth.
經由專一且不可逆的抑制ornithine decarboxylase 作用，eflornithine 具有抗腫瘤、抗原蟲、和抗毛髮生長的作用。Ornithine decarboxylase (ODC)是合成putrescine，spermine 及spermidine (這些被稱為聚胺Polyamine)時的速率限制酵素(rating-limiting enzyme)。
生化途徑製造聚胺，但所有的哺乳類的細胞須依賴 ornithine decarboxylase 來製造聚胺。Eflornithine 抑制 ODC 以及快速耗盡動物細胞的putrescine 和spermidine，而spermine 的濃度保持一樣或甚至於增加。快速分裂的細胞容易受到eflornithine 作用而產生影響。
Cream: For topical use only. This product will not prevent hair growth, but will decrease the rate of growth. You will still need to use hair removal techniques, such as shaving and plucking, while using eflornithine cream. Wait at least 5 minutes after removing hair to apply cream. Improvement can be seen within 4-8 weeks of use. Following discontinuation of use, pretreatment hair growth will be seen in about 8 weeks. Contact prescriber if skin irritation or intolerance develop. Do not wash affected area for at least 8 hours following application. You may apply cosmetics or make-up over the affected area once the cream has dried.
Injection:For I.V. use only; not for I.M. administration.
Must be diluted before use; frequent monitoring for myelosuppression
should be done; use with caution in patients with a history of seizures
and in patients with renal impairment; serial audiograms should be
obtained; due to the potential for relapse, patients should be followed
up for at least 24 months.