快樂小藥師
本部落格為介紹醫藥相關知識部落格,並沒有販賣藥品。此外文章部分內容可能會引起您的不安或是心理不適,在按下繼續閱讀前,請先自我評估,謝謝(原創文章如需轉載請先告知 左右水平廣告輪播-語法
  • // 如果你希望圖片繼續多一點,那就自己再複製增加

Eflornithine(Vaniqa)不是威而剛(Viagra)哦


先看長相:

vaniqa_with_box.jpg  

用途:

Cream: Females ≥12 years: Reduce unwanted hair from face and adjacent areas under the chin 



女性臉部毛髮清除,尤其是靠近下巴的地方

不過聽說他也有針劑:Treatment of meningoencephalitic stage of Trypanosoma brucei gambiense infection (sleeping sickness),簡單的說,就是非洲睡眠症,在台灣算是孤兒藥吧


用法:

Unwanted facial hair (Females): Topical: Apply thin layer of cream to affected areas of face and adjacent chin twice daily, at least 8 hours apart.

Treatment of infections caused by Trypanosoma : I.V. infusion (orphan drug): 100 mg/kg/dose given every 6 hours (over at least 45 minutes) for 14 days.

Dosing: Pediatric

Unwanted facial hair (females): Children ≥12 years: Refer to adult dosing.


 

機轉:

Eflornithine exerts antitumor and antiprotozoal effects through specific, irreversible (“suicide”) inhibition of the enzyme ornithine decarboxylase (ODC). ODC is the rate-limiting enzyme in the biosynthesis of putrescine, spermine, and spermidine, the major polyamines in nucleated cells. Polyamines are necessary for the synthesis of DNA, RNA, and proteins and are, therefore, necessary for cell growth and differentiation. Although many microorganisms and higher plants are able to produce polyamines from alternate biochemical pathways, all mammalian cells depend on ornithine decarboxylase to produce polyamines. Eflornithine inhibits ODC and rapidly depletes animal cells of putrescine and spermidine; the concentration of spermine remains the same or may even increase. Rapidly dividing cells appear to be most susceptible to the effects of eflornithine. Topically, the inhibition of ODC in the skin leads to a decreased rate of hair growth.




經由專一且不可逆的抑制ornithine decarboxylase 作用,eflornithine 具有抗腫瘤、抗原蟲、和抗毛髮生長的作用。Ornithine decarboxylase (ODC)是合成putrescine,spermine 及spermidine (這些被稱為聚胺Polyamine)時的速率限制酵素(rating-limiting enzyme)。
聚胺是合成DNA、RNA 和蛋白質時所必須的原料之一,因此是細胞生長和分化所必須的。雖然許多微生物和高等植物可以從其他的

生化途徑製造聚胺,但所有的哺乳類的細胞須依賴 ornithine decarboxylase 來製造聚胺。Eflornithine 抑制 ODC 以及快速耗盡動物細胞的putrescine 和spermidine,而spermine 的濃度保持一樣或甚至於增加。快速分裂的細胞容易受到eflornithine 作用而產生影響。


 

懷孕與授乳:

沒有明確研究,而且也會分泌到乳汁當中,所以會建議停止使用。


特別注意:

Cream: For topical use only. This product will not prevent hair growth, but will decrease the rate of growth. You will still need to use hair removal techniques, such as shaving and plucking, while using eflornithine cream. Wait at least 5 minutes after removing hair to apply cream. Improvement can be seen within 4-8 weeks of use. Following discontinuation of use, pretreatment hair growth will be seen in about 8 weeks. Contact prescriber if skin irritation or intolerance develop. Do not wash affected area for at least 8 hours following application. You may apply cosmetics or make-up over the affected area once the cream has dried.


Injection:For I.V. use only; not for I.M. administration. Must be diluted before use; frequent monitoring for myelosuppression should be done; use with caution in patients with a history of seizures and in patients with renal impairment; serial audiograms should be obtained; due to the potential for relapse, patients should be followed up for at least 24 months.


創作者介紹
創作者 快樂小藥師 的頭像
快樂小藥師

快樂小藥師 Im pharmacist nichts glücklich

快樂小藥師 發表在 痞客邦 留言(1) 人氣()


留言列表 (1)

發表留言
  • ssagy
  • 請問台灣有進這個藥嗎?

您尚未登入,將以訪客身份留言。亦可以上方服務帳號登入留言

請輸入暱稱 ( 最多顯示 6 個中文字元 )

請輸入標題 ( 最多顯示 9 個中文字元 )

請輸入內容 ( 最多 140 個中文字元 )

請輸入左方認證碼:

看不懂,換張圖

請輸入驗證碼