article-2095087-118E2C31000005DC-943_468x422  

這個藥物其實之前介紹過:

[US pharmacist]New Drug Review 2012 新藥回顧

結構:
Abiraterone  
不過這邊把一些收集到的機轉圖給各位參考:
F1.large  
機轉:
Abiraterone acetate is metabolized to abiraterone, an androgen biosynthesis inhibitor of CYP17 which decreases androgen levels and deprives androgen-sensitive prostatic carcinomas. It accomplishes this by interfering with the CYP17-catalyzed reactions involved in the production of dehydroepiandrosterone (DHEA) and androstenedione. Inhibition of CYP17 can result in increased mineralocorticoid production by the adrenals  
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