最近開始有一些新藥在使用了,例如

AVP1的藥物:Conivaptan。

AVP2的藥物:Tolvaptan還有一些研究中的Lixivaptan、Mozavaptan、Satavaptan。

所以就整理一下圖片如下:

 

Vasopressin V2 receptor activation. The binding of arginine vasopressin (AVP) to the V2 vasopressin receptor (V2R) stimulates a Gs-coupled protein that activates adenylyl cyclase, in turn causing production of cAMP to activate protein kinase A (PKA). This pathway increases the exocytosis of aquaporin water channel–containing vesicles (AQMCV) and inhibits endocytosis of the vesicles, both resulting in increases in aquaporin 2 (AQ2) channel formation and apical membrane insertion. This allows an increase in the permeability of water from the collecting duct (CD).

 

 

Vasopressin V2 receptor activation. The binding of arginine vasopressin (AVP) to the V2 vasopressin receptor (V2R) stimulates a Gs-coupled protein that activates adenylyl cyclase, in turn causing production of cAMP to activate protein kinase A (PKA). This pathway increases the exocytosis of aquaporin water channel–containing vesicles (AQMCV) and inhibits endocytosis of the vesicles, both resulting in increases in aquaporin 2 (AQ2) channel formation and apical membrane insertion. This allows an increase in the permeability of water from the collecting duct (CD).

 

 

資料來源:Arginine Vasopressin Antagonists for the Treatment of Heart Failure and Hyponatremia 

Circulation.2008; 118: 410-421 doi: 10.1161/ CIRCULATIONAHA.108.765289

 

其他的圖解:

 

 

整體血壓機轉在這邊:

圖解藥理學 18 血壓用藥 ver.08.1

 

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