螢幕快照 2017-08-11 14.37.49.png

最近剛好遇到患者因為避孕藥的副作用需要換藥,所以整理一下黃體素甚至是避孕藥的成分比較

順便看一下之前的比較

常見避孕藥比較

之前都是查詢2008的文獻:Reprint of Classification and pharmacology of progestins
但是我覺得距離2017有點久了,所以我找了2013年的,接著我就直接把文獻裡面的圖表貼上來了(Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects)

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最後補充一點表格(uptodate Overview of the use of estrogen-progestin contraceptives
This topic last updated: Aug 17, 2016)

Level of androgenic activity of progestins in contraceptive pills

Level of activity

Androgenic brand name(s)

High

Norgestrel

Levonorgestrel

Middle

Norethindrone

Norethindrone acetate

Low

Ethynodiol

Norgestimate

Desogestrel

Drospirenone

Dienogest

 

Pregnancy rate (percent) during first year of use of contraceptives

 

Typical use

Correct use

Most effective

Intrauterine device

Copper T or Mirena

<1

<1

Etonogestrel implant

<1

<1

Female sterilization

<1

<1

Vasectomy

<1

<1

Effective

Depo-Provera (DMPA) injection

6

<1

Contraceptive patch

9

<1

Contraceptive pills

Progestin-only or combination estrogen-progestin

9

<1

Contraceptive vaginal ring

9

<1

Diaphragm

12

6

Least effective

Condom

Male

18

2

Female

21

5

Sponge

Previous births

24

20

No previous births

12

9

Cervical cap (FemCap)

No previous births 

14

 N/A

Previous births 

29

 N/A

Fertility awareness-based methods

Cervical mucus or ovulation

24

3

Symptothermal

24

0.4

TwoDay

24

4

Standards days

24

5

Withdrawal

22

4

Spermicides

28

18

No method

85

85

 

Selected hormonal contraceptives: Oral contraceptives (birth control pills) and other delivery methods

US trade name (manufacturer)

Progestin (mg)*

Estrogen (micrograms)

Monophasic combinations

Beyaz 28 (Bayer)Δ◊

Drospirenone (3)

Ethinyl estradiol (20)

Gianvi 28 (Teva)Δ§

Loryna 28 (Sandoz)Δ§

Nikki 28 (Lupin)Δ§

Yaz (Bayer)Δ§

Aviane 28 (Teva Women's)

Levonorgestrel (0.1)

Ethinyl estradiol (20)

Falmina 28 (Northstar)

Lessina 28 (Teva Women's)

Lutera 28 (Actavis)

Orsythia 28 (Qualitest)

Sronyx 28 (Actavis)

Gildess Fe 1/20 (Qualitest)¥‡

Norethindrone acetate (1)

Ethinyl estradiol (20)

Junel Fe 1/20 28 (Teva Women's)

Larin Fe 1/20 (Teva Women's)¥‡

Loestrin Fe 1/20 28 (Warner Chilcott)

Loestrin 24 Fe (Warner Chilcott)

Microgestin Fe 1/20 28 (Actavis)

Tarina Fe 1/20 (Afaxys)

Apri 28 (Teva Women's)

Desogestrel (0.15)

Ethinyl estradiol (30)

Desogen 28 (Merck)

Emoquette 28 (Qualitest)

Juleber 28 (Northstar)

Ortho-Cept 28 (Janssen)

Reclipsen 28 (Actavis)

Solia 28 (Prasco)

Ocella 28 (Teva Women's)

Drospirenone (3)

Ethinyl estradiol (30)

Syeda 28 (Sandoz)

Yasmin 28 (Bayer)

Zarah 28 (Watson)

Altavera 28 (Sandoz)

Levonorgestrel (0.15)

Ethinyl estradiol (30)

Chateal 28 (Afaxys)

Kurvelo 28 (Lupin)

Levora 28 (Actavis)

Marlissa 28 (Glenmark)

Portia 28 (Teva Women's)

Gildess Fe 1.5/30 (Qualitest)¥‡

Norethindrone acetate (1.5)

Ethinyl estradiol (30)

Junel FE 1.5/30 (Teva Women's)¥‡

Larin FE 1.5/30 (Northstar)¥‡

Loestrin Fe 1.5/30 28 (Teva Women's)

Microgestin Fe 1.5/30 28 (Actavis)

Junel Fe 1.5/30 28 (Teva Women's)

Cryselle 28 (Teva Women's)¥

Norgestrel¥ (0.3)

Ethinyl estradiol (30)

Elinest 28 (Northstar)

Low-Ogestrel 28 (Actavis)¥

Kelnor 28 (Teva Women's)

Ethynodiol diacetate (1)

Ethinyl estradiol (35)

Zovia 1/35E 28 (Actavis)

Balziva 28 (Teva's Women's)

Norethindrone (0.4)

Ethinyl estradiol (35)

Briellyn 28 (Glenmark)

Femcon Fe 28 chewable (Actavis)

Gildagia 28 (Qualitest)

Ovcon 35 28 (Actavis)¥

Philith 28 (Northstar)

Vyfemla (Lupin)

Wymza Fe 28 chewable (Warner Chilcott)

Zenchent Fe 28 chewable (Watson)

Brevicon 28 (Actavis)

Norethindrone (0.5)

Ethinyl estradiol (35)

Modicon 28 (Janssen)

Necon 0.5/35 28 (Actavis)

Nortrel 0.5/35 28 (Teva Women's)

Wera (Northstar)

Alyacen 1/35 28 (Glenmark)

Norethindrone (1)

Ethinyl estradiol (35)

Cyclafem 1/35 (Qualitest)

Dasetta 1/35 28 (Northstar)

Necon 1/35 28 (Actavis)

Norinyl 1+35 28 (Actavis)

Nortrel 1/35 28 (Teva Women's)¥

Ortho-Novum 1/35 28 (Janssen)

Pirmella 1/35 (Lupin)

Estarylla (Sandoz)

Norgestimate (0.25)

Ethinyl estradiol (35)

Mono-Linyah (Northstar)

MonoNessa 28 (Actavis)

Ortho-Cyclen 28 (Janssen)

Previfem 28 (Vintage)

Sprintec 28 (Teva Women's)

Cyestra-35 (Paladin)Δ, Diane-35 (Bayer)Δ, Novo-Cyproterone/Ethinyl estradiol (Novopharm)Δ

NOTE: Cyproterone hormonal contraceptive products are not available in US; Canadian trade names shown

Cyproterone (2)

Ethinyl estradiol (35)

Zovia 1/50E 28 (Actavis)

Ethynodiol diacetate (1)

Ethinyl estradiol (50)

Ogestrel 0.5/50 28 (Actavis)

Norgestrel** (0.5)

Ethinyl estradiol (50)

Necon 1/50 28 (Actavis)

Norethindrone (1)

Mestranol (50)

Norinyl 1+50 28 (Actavis)

Multiphasic combinations

Natazia (Bayer)

Dienogest (0,2,3,0)

Estradiol valerate (3,2,2,1)

Lo Loestrin Fe (Actavis)¶¶

Norethindrone acetate (1,0)

Ethinyl estradiol (10,10)

Azurette 28 (Actavis)

Desogestrel (0.15,0,0)

Ethinyl estradiol (20,0,10)

Kariva 28 (Teva Women's)

Kimidess 28 (Qualitest)

Mircette 28 (Teva Women's)

Pimtrea 28 (Northstar)

Viorele 28 (Glenmark)

Estrostep Fe 28 (Actavis)Δ

Norethindrone acetate (1,1,1)

Ethinyl estradiol (20,30,35)

Tilia Fe 28 (Actavis)

Tri-Legest Fe 28 (Teva Women's)

Ortho Tri-Cyclen Lo 28 (Janssen)

Norgestimate (0.18,0.215,0.25)

Ethinyl estradiol (25,25,25)

Caziant 28 (Actavis)

Desogestrel (0.1,0.125,0.15)

Ethinyl estradiol (25,25,25)

Cesia 28 (Prasco)

Cyclessa 28 (Merck)

Velivet (Teva Women's)

Enpresse-28 (Duramed)

Levonorgestrel (0.05,0.075,0.125)

Ethinyl estradiol (30,40,30)

Levonest 28 (Northstar)

Myzilra 28 (Qualitest)

Trivora 28 (Actavis)

Ortho Tri-Cyclen 28 (Janssen)Δ¥

Norgestimate (0.18,0.215,0.25)

Ethinyl estradiol (35,35,35)

Tri-Estarylla (Sandoz)

TriNessa 28 (Actavis)

Tri-Previfem 28 (Qualitest)

Tri-Sprintec 28 (Teva Women's)

Alyacen 7/7/7 28 (Glenmark)

Norethindrone (0.5,0.75,1)

Ethinyl estradiol (35,35,35)

Cyclafem 7/7/7 28 (Qualitest)

Dasetta 7/7/7 28 (Northstar)

Necon 7/7/7 28 (Actavis)

Nortrel 7/7/7 28 (Teva Women's)¥

Ortho-Novum 7/7/7 28 (Janssen)

Pirmella 7/7/7 (Lupin)

Aranelle 28 (Teva Women's)

Norethindrone (0.5,1,0.5)

Ethinyl estradiol (35,35,35)

Leena 28 (Actavis)

Tri-Norinyl 28 (Actavis)

Norethindrone (0.5,1,0.5)

Ethinyl estradiol (35,35,35)

Extended combinationsΔΔ

Amethia Lo 91 (Actavis), Camresse Lo 91 (Teva), LoSeasonique 91 (Teva)

Levonorgestrel (0.1)

Ethinyl estradiol (20,10)

Quartette 91 (Teva)

Levonorgestrel (0.15)

Ethinyl estradiol (20,25,30,10)

Amethia 91 (Actavis), Camrese 91 (Teva), Daysee 91 (Lupin), Seasonique 91 (Teva)

Levonorgestrel (0.15)

Ethinyl estradiol (30,10)

Introvale 91, Jolessa 91 (Barr), Quasense 91 (Actavis)

Levonorgestrel (0.15)

Ethinyl estradiol (30)

Continuous combinations

Amethyst 28 (Actavis), Ashlyna 28 (Glenmark)

Levonorgestrel (0.09)

Ethinyl estradiol (20)

Progestin-only

Camila 28 (Teva Women's)

Norethindrone (0.35)

None

Debiltane (Northstar)

Errin 28 (Teva Women's)

Heather (Glenmark)

Jencycla (Lupin)

Jolivette 28 (Actavis)

Lyza 28 (Afaxys)

Nora-BE 28 (Actavis)

Norlyroc (Ohm Laboratories)

Nor-QD 28 (Actavis)

Ortho Micronor (Janssen)

Other delivery methods

Ortho Evra (Janssen), Xulane (Mylan) transdermal patch (weekly)

Norelgestromin (releases 0.15 mg/day)

Ethinyl estradiol (releases 35 mcg/day)

NuvaRing vaginal ring (Organon)

Etonogestrel (releases 0.12 mg/day)

Ethinyl estradiol (releases 15 mcg/day)

 

 

 

 

 

 

 

 

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