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上次跟大家提過wafarin會減少體內的維生素K,這次就來看一下statin類降血脂藥會抑制維生素K還有CoQ10的生成,導致血鈣會沉積在心血管管壁粒線體功率下降。

由於statins抑制了維生素K的生成誘發matrix Gla protein的活性下降,造成鈣離子大量沉積在心臟血管關閉的平滑肌。

Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6.

Abstract

In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', and thereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. We propose that current statin treatment guidelines be critically reevaluated.

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