Traumatic brain injury (TBI) is an unfortunately common cause of death and disability among people of all ages. In addition to the primary injury to the brain resulting from the initial impact, a variety of secondary injuries contribute to morbidity stemming in part from high intracranial pressure (ICP) and resultant reductions in cerebral perfusion, leading to ischemia. Therapy to minimize this secondary injury includes ICP management, and a recent trial (Bulger et al, 2010) examined whether rapid administration of hypertonic fluids, a well-known measure that reduces ICP, would lead to better outcomes in TBI patients.
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