快樂小藥師 Im pharmacist nichts glücklich

John V. Fahy, M.D., and Burton F. Dickey, M.D.

[Micromedex][01] acetylcysteine 適應症整理

[Micromedex][02]Acetylcysteine適應症整理

[Micromedex][03]Acetylcysteine適應症整理

[Micromedex][04]Acetylcysteine 適應症整理

第22～35

[Micromedex][01] acetylcysteine 適應症整理

[Micromedex][02]Acetylcysteine適應症整理

[Micromedex][03]Acetylcysteine適應症整理

第13～第21

接上篇

[Micromedex][01] acetylcysteine 適應症整理

[Micromedex][02]Acetylcysteine適應症整理

[Micromedex][04]Acetylcysteine 適應症整理
[Micromedex][05]Acetylcysteine適應症整理

這次是第7～第12

接著上一次的文章，這次是第2～第6

Acetylcysteine的功能很多，大家如果還有點印象，可以參考這邊：

1. N-Acetyl-L-Cysteine 用於美白 
   
2. N acetylcysteine對Acetaminophen的中毒治療 
   
3. Acetaminophen與Acetylcysteine併用？
4. 老藥新用：Acetylcysteine預防X光照相術顯影劑之腎毒性

之前也幫大家簡單整理過：

認識 N acetylcysteine

這次我就從幾個資料庫挑出他的適應症給大家參考：

Nature Medicine Volume:16,Pages:1194–1195 Year published: (2010) DOI: doi:10.1038/nm1110-1194 Published online 04 November 2010

In Crohn's disease, immune damage to the gut wall is both induced and modified by the gut microflora, challenging researchers to solve the maze of interactions exploitable for therapeutic benefit. Whether these microbial 'guests' are worsening or helping in this scenario is still open to debate. In 'Bench to Bedside', Warren Strober highlights mice studies showing that certain microbes in the gut have a protective role promoting a shift towards an increased regulatory response that protects from recurrence of the disease. In 'Bedside to Bench', Thomas MacDonald examines how human studies using strategies to block soluble proinflammatory cytokines—despite solid supporting data from animal models—have shown disappointing results compared with therapies that neutralize soluble cytokines but also deplete proinflammatory cells, calling into question whether targeting a single soluble cytokine will ever be useful to treat people with Crohn's disease.

Traumatic brain injury (TBI) is an unfortunately common cause of death and disability among people of all ages. In addition to the primary injury to the brain resulting from the initial impact, a variety of secondary injuries contribute to morbidity stemming in part from high intracranial pressure (ICP) and resultant reductions in cerebral perfusion, leading to ischemia. Therapy to minimize this secondary injury includes ICP management, and a recent trial (Bulger et al, 2010) examined whether rapid administration of hypertonic fluids, a well-known measure that reduces ICP, would lead to better outcomes in TBI patients.

Marcel J. Casavant
Chief, Pharmacology-Toxicology, Nationwide Children's Hospital; Medical Director, Central Ohio Poison Center; Clinical Professor, The Ohio State University Colleges of Medicine and Pharmacy
Jill RK Griffith
Clinical Pharmacist, Mount Carmel West Hospital; Clinical Assistant Professor, The Ohio State University College of Pharmacy

上次有跟各位介紹過這個產品：Suile速瘉樂試用心得

David J. Kuter, M.D., D.Phil., Mathias Rummel, M.D., Ralph Boccia, M.D., B. Gail Macik, M.D., Ingrid Pabinger, M.D., Dominik Selleslag, M.D., Francesco Rodeghiero, M.D., Beng H. Chong, M.D., Xuena Wang, Ph.D., and Dietmar P. Berger, M.D., Ph.D.

如果這個月都有看我的網誌，對這個藥就不陌生了：

[Drugs]Current and Future Management Options for Myelodysplastic Syndromes 骨髓發育不全症候群的治療與展望

Eltrombopag for the Treatment of Chronic Idiopathic Thrombocytopenic Purpura

紫斑症 Idiopathic Thrombocytopenic Purpura

最近健保給付放寬了，所以有很多患者受惠可以使用iressa或是tarceva。

不過隨著藥物藥效的產生，這類型的患者也會遭遇到一些不便，其中一個，就是甲溝炎。

上次跟各位提過瘀青（喜療妥 hirudoid 試用），這次來講一個跟瘀青很類似，但是嚴重很多的疾病：紫斑症。

之前也有跟各位簡單介紹過：

Eltrombopag for the Treatment of Chronic Idiopathic Thrombocytopenic Purpura

雖然說我對Micromedex的資料一直很有意見，但是不可否認的，他還是堪稱目前資料量最大的資料庫，而他最近也提供很多地方使用2.0的版本了，附帶一提，如果你有iphone等設備，也可以直接去下載2.0來用。

從小到大瘀青的經驗一定不少，不過瘀青時你都怎樣處理呢？

By Nancy A. Melville
Medscape Medical News

關於燙傷，這邊已經提過很多次了，例如：

燒燙傷知識簡介

燙傷藥膏

今天來看一個對於輕度燙傷的東西：

Laurie Barclay, MD