快樂小藥師 Im pharmacist nichts glücklich

Becaplermin（Regranex®）

別將他和Repronex搞混了，那是Menotropins，不一樣。

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臨床用途：

Adjunctive treatment of diabetic neuropathic ulcers occurring on the lower limbs and feet that extend into subcutaneous tissue (or beyond) and have adequate blood supply

糖尿病患下肢或延伸至皮下組織且有充足血流的潰瘍

外觀：

既然是藥膏，就是直接塗抹在傷口處

Diabetic ulcers (lower extremity): Topical: Apply appropriate amount of gel once daily with a cotton swab or similar tool, as a coating over the ulcer. The amount of becaplermin to be applied will vary depending on the size of the ulcer area.

Note: If the ulcer does not decrease in size by ~30% after 10 weeks of treatment or complete healing has not occurred in 20 weeks, continued treatment with becaplermin gel should be reassessed.

Estimation of gel requirement: To calculate the length of gel applied to the ulcer, measure the greatest length of the ulcer by the greatest width of the ulcer. Tube size and unit of measure will determine the formula used in the calculation. Recalculate amount of gel needed every 1-2 weeks, depending on the rate of change in ulcer area.

Centimeters:

15 g tube: [ulcer length (cm) x width (cm)] divided by 4 = length of gel (cm)

2 g tube: [ulcer length (cm) x width (cm)] divided by 2 = length of gel (cm)

懷孕分級：C，不建議哺乳

機轉：

Recombinant B-isoform homodimer of human platelet-derived growth factor (rPDGF-BB) which enhances formation of new granulation tissue, induces fibroblast proliferation and differentiation to promote wound healing; also promotes angiogenesis.