節錄自:Critical Care Handbook of the Massachussetts General Hospital, 5th Edition
Type of Lesion |
Examples |
Comments |
Acute viral hepatitis-like reaction |
Diclofenac, halothane, isoflurane, isoniazid, methyldopa, phenytoin |
Mortality rate much higher than that of viral hepatitis; histologic pattern of bridging necrosis in severe cases |
Zonal necrosis |
Acetaminophen, carbon tetrachloride |
Dose dependent; negligible inflammatory response; lesions predominantly restricted to one lobular zone |
Steatohepatitis, alcoholic hepatitis-like reaction |
Amiodarone, perhexiline, nifedipine, valproic acid |
|
Steatohepatitis, microvesicular |
Aspirin, tetracycline, zidovudine |
|
Cholestasis |
Angiotensin-converting enzyme inhibitors, carbamazepine, chlorpromazine, cimetidine, cotrimoxazole, dextropropoxyphene, erythromycin, estrogens, flucloxacillin, haloperidol, sulfonamides, tricyclic antidepressants |
Histologically, inflammatory, noninflammatory, and forms with bile duct destruction can be recognized |
Granulomatous hepatitis |
Allopurinol, diltiazem, quinidine, phenytoin, procainamide, sulfonamides |
Histiocytes and eosinophiles in the granulomas reflect a hypersensitivity reaction |
Veno-occlusive disease |
Chemotherapeutic drugs |
Lesions are dose dependent |
Chronic hepatitis |
Amiodarone, aspirin, diclofenac, isoniazid, methyldopa, phenytoin, nitrofurantoin, trazodone |
Occurs with continued exposure to a drug; in most cases, hepatitis resolves after discontinuation of the drug |
Adenomas, hepatocellular carcinomas |
Estrogens, anabolic hormones |
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