針對常見的非固醇類抗發炎藥物的還氧化酶抑制劑比較表
|
Drug |
Type |
Indication |
COX isoform selectivity |
Comments |
|
|
Aceclofenac |
Phenylacetate |
RA, OA, AS |
|
|
|
|
Acemetacin |
Indole ester |
RD, OA, MS, PO |
|
Ester of indometacin |
|
|
Aspirin |
Salicylate |
|
Weakly COX-1 selective |
Mainly cardiovascular usage alone Component of many OTC preparations |
|
|
Azapropazone |
Pyrazolone |
RD, AS, G |
|
Used when other drugs have failed Severe gastrointestinal effects |
|
|
Celecoxib |
Coxib |
RA, OA, AS, H&M |
Moderately COX-2 selective |
Fewer gastrointestinal effects |
|
|
Dexibruprofen |
Propionate |
OA, MS, D, H&M |
|
Active enantiomer of ibuprofen |
|
|
Dexketoprofen |
Propionate |
PO, D, H&M |
|
Isomer of ketoprofen |
|
|
Diclofenac |
Phenylacetate |
RA, OA, G, MS, PO |
Weakly COX-2 selective |
Moderate potency |
|
|
Etodolac |
Pyranocarboxylate |
RA, OA |
|
Possibly fewer gastrointestinal effects |
|
|
Etoricoxib |
Coxib |
RA, OA, G |
Very COX-2 selective |
|
|
|
Fenbufen |
Propionate |
RA, OA, MS |
|
|
|
|
Fenoprofen |
Propionate |
RA, OA, MS, PO |
Non-selective |
Prodrug activated in liver |
|
|
Flurbiprofen |
Propionate |
RA, OA, MS, PO, D, H&M |
Very COX-1 selective |
|
|
|
Ibuprofen |
Propionate |
RA, OA, MS, PO, D, H&M |
Weakly COX-1 selective |
Suitable for children |
|
|
Indometacin |
Indole |
RA, OA, G, MS, PO, D |
Weakly COX-1 selective |
Suitable for moderate to severe disease |
|
|
Ketoprofen |
Propionate |
RA, OA, G, MS, PO |
|
Suitable for mild disease |
|
|
Ketorolac |
Pyrrolizine |
PO |
Highly COX-1 selective |
|
|
|
Mefenamic acid |
Fenamate |
RA, OA, PO, D |
|
Moderate activity |
|
|
Meloxicam |
Oxicam |
RA, OA, AS |
|
Possibly fewer gastrointestinal effects |
|
|
Nabumetone |
Naphthylalkenone |
RA, OA |
|
Prodrug activated in liver |
|
|
Naproxen |
Propionate |
RA, OA, G, MS, PO, D |
Weakly COX-1 selective |
|
|
|
Parecoxib |
Coxib |
PO |
|
Prodrug activated in liver |
|
|
Piroxicam |
Oxicam |
RA, OA, G, MS, PO |
Weakly COX-2 selective |
|
|
|
Sulindac |
Indene |
RA, OA, G, MS |
Weakly COX-2 selective |
Prodrug |
|
|
Tenoxicam |
Oxicam |
RA, OA, MS |
|
|
|
|
Tiaprofenic acid |
Propionate |
RA, OA, MS |
|
|
|
|
Tolfenamic acid |
Fenamate |
H&M |
|
|
|
|
AS, ankylosing spondylitis; D, dysmenorrhoea; G, acute gout; H&M, headache and migraine; MS, musculoskeletal injuries and pain; OA, osteoarthritis; OTC, over-the-counter; PO, postoperative pain; RA, rheumatoid arthritis. (Data from British National Formulary and Warner T D, Mitchell J A 2004 FASEB J 18: 790-804.) |
|
||||
留言列表
醫藥類 (14)
