快樂小藥師 Im pharmacist nichts glücklich

商品名：Firmagon

跟cetrorelix很像，但是治療的適應症是不一樣的，這個藥物是用在前列腺癌的治療。

這是一家大家比較不熟的藥廠：Ferring Pharmaceuticals 

他有名的藥物是EUFLEXXA(R), (1% sodium hyaluronic acid), BRAVELLE(R) (urofollitropin for injection, purified), MENOPUR(R) and REPRONEX(R) (menotropins for injection, USP), Novarel(R) (chorionic gonadotropin for injection, USP), ENDOMETRIN(R) (progesterone) Vaginal Insert, ACTHREL(R) (corticorelin ovine triflutate for injection), PROSED(R) DS (methenamine, phenyl salicylate, methylene blue, benzoic acid, hyoscyamine sulfate), and DESMOPRESSIN. 
廠商連結在這邊：http://www.ferringusa.com/products/urology 

prostate CA, advanced

80 mg SC q4wk

Start: 240 mg SC x1, given as 2 x 120 mg injections

Pharmacology

Binds reversibly to the pituitary gonadotropin-releasing hormone (GnRH) receptors, thereby reducing the release of gonadotropin and consequently testosterone.

Pharmacokinetics

Absorption

C _max and AUC are approximately 26 ng/mL and 1,054 ng•day/mL, respectively. T _max is 2 days. Pharmacokinetics are strongly influenced by the injection concentration.

Distribution

Vd after IV (more than 1 L/kg) or subcutaneous (more than 1,000 L) administration indicates drug distribution throughout total body water. Plasma protein binding is approximately 90%.

Metabolism

Metabolism is due to peptide hydrolysis during hepatobiliary system passage.

Elimination

Excretion is primarily as peptide fragments in the feces (70% to 80%) and approximately 20% to 30% is renally excreted. Median terminal half-life is approximately 53 days. Cl is approximately 9 L/h.

General Advice

• Administer the first maintenance dose 28 days after the starting dose.
• Administer as a subcutaneous dose in the abdominal region, varying the site periodically.
• Inject into areas of the abdomen that will not be exposed to pressure (eg, not close to the waistband).
• Gloves should be worn during preparation and administration.
• Keep vial vertical at all times.
• Do not shake the vial.
• Do not reconstitute with bacteriostatic water for injection.
• Administer within 1 h after reconstitution with sterile water for injection.

附上前列腺癌協會：http://www.prostatecancerliving.com/en/pcl-homep/pcl-homep/accessser/0/178/178/default.html