快樂小藥師 Im pharmacist nichts glücklich

Journal Scan Summary

Citation:  J Am Coll Cardiol 2014;Mar 28:[Epub ahead of print].
[Free full-text JACC article PDF]

Perspective:
The following are 10 points to remember about the 2014 guideline for the management of patients with nonvalvular atrial fibrillation (AF):

1. In assessing risk of stroke in a patient with nonvalvular AF, the writing committee recommends (Class I) the usage of the CHA₂DS₂-VASc (C=congestive heart failure; H=hypertension; A₂=age ≥75 years [doubled]; D=diabetes mellitus; S₂=stroke, transient ischemic attack, or thromboembolism [doubled]; V=vascular disease; A=age 65-74 years; Sc=sex category, i.e., female gender) score, as opposed to the CHADS₂ score.

2. For nonvalvular AF patients with a history of stroke or transient ischemic attack, or a CHA₂DS₂-VASc score ≥2, oral anticoagulation is recommended (Class I). Options for oral anticoagulation include warfarin, dabigatran, rivaroxaban, and apixaban.

3. For patients with nonvalvular AF and a CHA₂DS₂-VASc score of 0, it is reasonable to omit antithrombotic therapy (Class IIa).

4. The following options may be considered with a patient with nonvalvular AF and a CHA₂DS₂-VASc score of 1: no antithrombotic therapy, oral anticoagulation, or aspirin (Class IIb).

5. None of the novel oral anticoagulants (dabigatran, rivaroxaban, or apixaban) are recommended to be used in patients with AF and a mechanical or bioprosthetic heart valve (Class III harm).

6. As in the earlier guidelines, the committee recommends against the use of certain antiarrhythmic medications (flecainide, propafenone, dofetilide, and sotalol) in patients with severe left ventricular hypertrophy (LVH). In the current guidelines, severe LVH is now defined as wall thickness exceeding 1.5 cm.

7. Oral anticoagulation should be prescribed to patients with hypertrophic cardiomyopathy and AF irrespective of the CHA₂DS₂-VASc score (Class I).

8. A randomized trial suggested that a lenient (<110 bpm) rate control strategy was as effective as a strict strategy (<80 bpm) in patients with persistent/permanent AF. However, the writing committee still advocates for the latter (Class IIa), as the results of this single trial were not thought to be definitive.

9. Catheter ablation is useful in patients with symptomatic, paroxysmal AF who have not responded to or tolerated antiarrhythmic medications (Class I).

10. Catheter ablation is also reasonable in selected patients with symptomatic, paroxysmal AF prior to a trial of medical therapy, provided that it can be performed at an experienced center (Class IIa).

Author(s):
Aman Chugh, M.D., F.A.C.C. (Disclosure)