最近剛好遇到患者因為避孕藥的副作用需要換藥，所以整理一下黃體素甚至是避孕藥的成分比較
順便看一下之前的比較
之前都是查詢2008的文獻：Reprint of Classification and pharmacology of progestins
但是我覺得距離2017有點久了，所以我找了2013年的，接著我就直接把文獻裡面的圖表貼上來了（Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects）
最後補充一點表格（uptodate Overview of the use of estrogen-progestin contraceptives
This topic last updated: Aug 17, 2016）
Level of androgenic activity of progestins in contraceptive pills
|
Level of activity |
Androgenic brand name(s) |
|
High |
Norgestrel |
|
Levonorgestrel |
|
|
Middle |
Norethindrone |
|
Norethindrone acetate |
|
|
Low |
Ethynodiol |
|
Norgestimate |
|
|
Desogestrel |
|
|
Drospirenone |
|
|
Dienogest |
Pregnancy rate (percent) during first year of use of contraceptives
|
|
Typical use |
Correct use |
|
Most effective |
||
|
Intrauterine device |
||
|
Copper T or Mirena |
<1 |
<1 |
|
Etonogestrel implant |
<1 |
<1 |
|
Female sterilization |
<1 |
<1 |
|
Vasectomy |
<1 |
<1 |
|
Effective |
||
|
Depo-Provera (DMPA) injection |
6 |
<1 |
|
Contraceptive patch |
9 |
<1 |
|
Contraceptive pills |
||
|
Progestin-only or combination estrogen-progestin |
9 |
<1 |
|
Contraceptive vaginal ring |
9 |
<1 |
|
Diaphragm |
12 |
6 |
|
Least effective |
||
|
Condom |
||
|
Male |
18 |
2 |
|
Female |
21 |
5 |
|
Sponge |
||
|
Previous births |
24 |
20 |
|
No previous births |
12 |
9 |
|
Cervical cap (FemCap) |
||
|
No previous births |
14 |
N/A |
|
Previous births |
29 |
N/A |
|
Fertility awareness-based methods |
||
|
Cervical mucus or ovulation |
24 |
3 |
|
Symptothermal |
24 |
0.4 |
|
TwoDay |
24 |
4 |
|
Standards days |
24 |
5 |
|
Withdrawal |
22 |
4 |
|
Spermicides |
28 |
18 |
|
No method |
85 |
85 |
Selected hormonal contraceptives: Oral contraceptives (birth control pills) and other delivery methods
|
US trade name (manufacturer) |
Progestin (mg)* |
Estrogen (micrograms)¶ |
|
Monophasic combinations |
||
|
Beyaz 28 (Bayer)Δ◊ |
Drospirenone (3) |
Ethinyl estradiol (20) |
|
Gianvi 28 (Teva)Δ§ |
||
|
Loryna 28 (Sandoz)Δ§ |
||
|
Nikki 28 (Lupin)Δ§ |
||
|
Yaz (Bayer)Δ§ |
||
|
Aviane 28 (Teva Women's) |
Levonorgestrel (0.1) |
Ethinyl estradiol (20) |
|
Falmina 28 (Northstar) |
||
|
Lessina 28 (Teva Women's) |
||
|
Lutera 28 (Actavis) |
||
|
Orsythia 28 (Qualitest) |
||
|
Sronyx 28 (Actavis) |
||
|
Gildess Fe 1/20 (Qualitest)¥‡ |
Norethindrone acetate (1) |
Ethinyl estradiol (20) |
|
Junel Fe 1/20 28 (Teva Women's)‡ |
||
|
Larin Fe 1/20 (Teva Women's)¥‡ |
||
|
Loestrin Fe 1/20 28 (Warner Chilcott)‡ |
||
|
Loestrin 24 Fe (Warner Chilcott)† |
||
|
Microgestin Fe 1/20 28 (Actavis)‡ |
||
|
Tarina Fe 1/20 (Afaxys) |
||
|
Apri 28 (Teva Women's) |
Desogestrel (0.15) |
Ethinyl estradiol (30) |
|
Desogen 28 (Merck) |
||
|
Emoquette 28 (Qualitest) |
||
|
Juleber 28 (Northstar) |
||
|
Ortho-Cept 28 (Janssen) |
||
|
Reclipsen 28 (Actavis) |
||
|
Solia 28 (Prasco) |
||
|
Ocella 28 (Teva Women's) |
Drospirenone (3) |
Ethinyl estradiol (30) |
|
Syeda 28 (Sandoz) |
||
|
Yasmin 28 (Bayer) |
||
|
Zarah 28 (Watson) |
||
|
Altavera 28 (Sandoz) |
Levonorgestrel (0.15) |
Ethinyl estradiol (30) |
|
Chateal 28 (Afaxys) |
||
|
Kurvelo 28 (Lupin) |
||
|
Levora 28 (Actavis) |
||
|
Marlissa 28 (Glenmark) |
||
|
Portia 28 (Teva Women's) |
||
|
Gildess Fe 1.5/30 (Qualitest)¥‡ |
Norethindrone acetate (1.5) |
Ethinyl estradiol (30) |
|
Junel FE 1.5/30 (Teva Women's)¥‡ |
||
|
Larin FE 1.5/30 (Northstar)¥‡ |
||
|
Loestrin Fe 1.5/30 28 (Teva Women's)‡ |
||
|
Microgestin Fe 1.5/30 28 (Actavis)‡ |
||
|
Junel Fe 1.5/30 28 (Teva Women's)‡ |
||
|
Cryselle 28 (Teva Women's)¥ |
Norgestrel¥ (0.3) |
Ethinyl estradiol (30) |
|
Elinest 28 (Northstar) |
||
|
Low-Ogestrel 28 (Actavis)¥ |
||
|
Kelnor 28 (Teva Women's) |
Ethynodiol diacetate (1) |
Ethinyl estradiol (35) |
|
Zovia 1/35E 28 (Actavis) |
||
|
Balziva 28 (Teva's Women's) |
Norethindrone (0.4) |
Ethinyl estradiol (35) |
|
Briellyn 28 (Glenmark) |
||
|
Femcon Fe 28 chewable (Actavis) |
||
|
Gildagia 28 (Qualitest) |
||
|
Ovcon 35 28 (Actavis)¥ |
||
|
Philith 28 (Northstar) |
||
|
Vyfemla (Lupin) |
||
|
Wymza Fe 28 chewable (Warner Chilcott) |
||
|
Zenchent Fe 28 chewable (Watson) |
||
|
Brevicon 28 (Actavis) |
Norethindrone (0.5) |
Ethinyl estradiol (35) |
|
Modicon 28 (Janssen) |
||
|
Necon 0.5/35 28 (Actavis) |
||
|
Nortrel 0.5/35 28 (Teva Women's) |
||
|
Wera (Northstar) |
||
|
Alyacen 1/35 28 (Glenmark) |
Norethindrone (1) |
Ethinyl estradiol (35) |
|
Cyclafem 1/35 (Qualitest) |
||
|
Dasetta 1/35 28 (Northstar) |
||
|
Necon 1/35 28 (Actavis) |
||
|
Norinyl 1+35 28 (Actavis) |
||
|
Nortrel 1/35 28 (Teva Women's)¥ |
||
|
Ortho-Novum 1/35 28 (Janssen) |
||
|
Pirmella 1/35 (Lupin) |
||
|
Estarylla (Sandoz) |
Norgestimate (0.25) |
Ethinyl estradiol (35) |
|
Mono-Linyah (Northstar) |
||
|
MonoNessa 28 (Actavis) |
||
|
Ortho-Cyclen 28 (Janssen) |
||
|
Previfem 28 (Vintage) |
||
|
Sprintec 28 (Teva Women's) |
||
|
Cyestra-35 (Paladin)Δ, Diane-35 (Bayer)Δ, Novo-Cyproterone/Ethinyl estradiol (Novopharm)Δ NOTE: Cyproterone hormonal contraceptive products are not available in US; Canadian trade names shown |
Cyproterone (2) |
Ethinyl estradiol (35) |
|
Zovia 1/50E 28 (Actavis) |
Ethynodiol diacetate (1) |
Ethinyl estradiol (50) |
|
Ogestrel 0.5/50 28 (Actavis) |
Norgestrel** (0.5) |
Ethinyl estradiol (50) |
|
Necon 1/50 28 (Actavis) |
Norethindrone (1) |
Mestranol¶ (50) |
|
Norinyl 1+50 28 (Actavis) |
||
|
Multiphasic combinations |
||
|
Natazia (Bayer) |
Dienogest (0,2,3,0) |
Estradiol valerate (3,2,2,1) |
|
Lo Loestrin Fe (Actavis)¶¶ |
Norethindrone acetate (1,0) |
Ethinyl estradiol (10,10) |
|
Azurette 28 (Actavis) |
Desogestrel (0.15,0,0) |
Ethinyl estradiol (20,0,10) |
|
Kariva 28 (Teva Women's) |
||
|
Kimidess 28 (Qualitest) |
||
|
Mircette 28 (Teva Women's) |
||
|
Pimtrea 28 (Northstar) |
||
|
Viorele 28 (Glenmark) |
||
|
Estrostep Fe 28 (Actavis)Δ |
Norethindrone acetate (1,1,1) |
Ethinyl estradiol (20,30,35) |
|
Tilia Fe 28 (Actavis) |
||
|
Tri-Legest Fe 28 (Teva Women's)‡ |
||
|
Ortho Tri-Cyclen Lo 28 (Janssen) |
Norgestimate (0.18,0.215,0.25) |
Ethinyl estradiol (25,25,25) |
|
Caziant 28 (Actavis) |
Desogestrel (0.1,0.125,0.15) |
Ethinyl estradiol (25,25,25) |
|
Cesia 28 (Prasco) |
||
|
Cyclessa 28 (Merck) |
||
|
Velivet (Teva Women's) |
||
|
Enpresse-28 (Duramed) |
Levonorgestrel (0.05,0.075,0.125) |
Ethinyl estradiol (30,40,30) |
|
Levonest 28 (Northstar) |
||
|
Myzilra 28 (Qualitest) |
||
|
Trivora 28 (Actavis) |
||
|
Ortho Tri-Cyclen 28 (Janssen)Δ¥ |
Norgestimate (0.18,0.215,0.25) |
Ethinyl estradiol (35,35,35) |
|
Tri-Estarylla (Sandoz) |
||
|
TriNessa 28 (Actavis) |
||
|
Tri-Previfem 28 (Qualitest) |
||
|
Tri-Sprintec 28 (Teva Women's) |
||
|
Alyacen 7/7/7 28 (Glenmark) |
Norethindrone (0.5,0.75,1) |
Ethinyl estradiol (35,35,35) |
|
Cyclafem 7/7/7 28 (Qualitest) |
||
|
Dasetta 7/7/7 28 (Northstar) |
||
|
Necon 7/7/7 28 (Actavis) |
||
|
Nortrel 7/7/7 28 (Teva Women's)¥ |
||
|
Ortho-Novum 7/7/7 28 (Janssen) |
||
|
Pirmella 7/7/7 (Lupin) |
||
|
Aranelle 28 (Teva Women's) |
Norethindrone (0.5,1,0.5) |
Ethinyl estradiol (35,35,35) |
|
Leena 28 (Actavis) |
||
|
Tri-Norinyl 28 (Actavis) |
Norethindrone (0.5,1,0.5) |
Ethinyl estradiol (35,35,35) |
|
Extended combinationsΔΔ |
||
|
Amethia Lo 91 (Actavis), Camresse Lo 91 (Teva), LoSeasonique 91 (Teva) |
Levonorgestrel (0.1) |
Ethinyl estradiol (20,10) |
|
Quartette 91 (Teva) |
Levonorgestrel (0.15) |
Ethinyl estradiol (20,25,30,10) |
|
Amethia 91 (Actavis), Camrese 91 (Teva), Daysee 91 (Lupin), Seasonique 91 (Teva) |
Levonorgestrel (0.15) |
Ethinyl estradiol (30,10) |
|
Introvale 91, Jolessa 91 (Barr), Quasense 91 (Actavis) |
Levonorgestrel (0.15) |
Ethinyl estradiol (30) |
|
Continuous combinations |
||
|
Amethyst 28 (Actavis), Ashlyna 28 (Glenmark) |
Levonorgestrel (0.09) |
Ethinyl estradiol (20) |
|
Progestin-only |
||
|
Camila 28 (Teva Women's) |
Norethindrone (0.35) |
None |
|
Debiltane (Northstar) |
||
|
Errin 28 (Teva Women's) |
||
|
Heather (Glenmark) |
||
|
Jencycla (Lupin) |
||
|
Jolivette 28 (Actavis) |
||
|
Lyza 28 (Afaxys) |
||
|
Nora-BE 28 (Actavis) |
||
|
Norlyroc (Ohm Laboratories) |
||
|
Nor-QD 28 (Actavis) |
||
|
Ortho Micronor (Janssen) |
||
|
Other delivery methods |
||
|
Ortho Evra (Janssen), Xulane (Mylan) transdermal patch (weekly) |
Norelgestromin (releases 0.15 mg/day) |
Ethinyl estradiol (releases 35 mcg/day) |
|
NuvaRing vaginal ring (Organon) |
Etonogestrel (releases 0.12 mg/day) |
Ethinyl estradiol (releases 15 mcg/day) |
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醫藥類 (14)
