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DRUG

GROUP

ASPIRATE

And instill

steroids⁰⁰¹

'SPREAD’ AND DILUTE

LOCALISE AND NEUTRALISE

SPECIFIC MANAGEMENT

ADDITIONAL

INFORMATION

Fluorouracil

2

Y

Y

Apply topical hydrocortisone and cover the area with an ice pack h for the next 4 hours. If the local reaction has then settled apply heat g for a further 24 to 48 hours. 2

Possibility of local inflammation. S/C hyaluronidase may facilitate dispersion of large volume extravasations in addition to the warm compressions

Gemcitabine

1

Y

Y

Infiltrate the site with hyaluronidase.a Apply heat and compression.2 g

Idarubicin

5

Y

Y

Apply topical DMSO, every 2 hours at the extravasation site followed by topical hydrocortisone cream and a cold compress. 1 h

Avoid contact with good skin. If blistering occurs, stop the DMSO and seek further advice. Sodium bicarbonate may have a role. Surgical excision e is sometimes required to prevent serious damage

Ifosfamide

1

Y

Y

Infiltrate the site with hyaluronidase.a Apply heat and compression.2 g

Unlikely to cause tissue damage

Irinotecan

3

Y

Y

Infiltrate with sodium bicarbonate into the area, followed by heat (i.e. warm compression.g)

Extravasation is rare

See j

Beta Interferons

1

Y

Y

Infiltrate the site with hyaluronidase.a Apply heat and compression. 2 g

Melphalan

1

Y

Y

Infiltrate the site with hyaluronidase.a Apply heat and compression. 2 g