快樂小藥師 Im pharmacist nichts glücklich

今天有學妹問我：學長，ccr5是什麼？腎功能嗎？

當然不是

根據我對學妹的了解，他應該是在念抗病毒藥

所以我猜大概是指：Maraviroc

Maraviroc is the first in a novel class of antiretroviral agents, CCR5 coreceptor antagonists

至於何謂CCR5

Mechanism of action of maraviroc. Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and gp120 must bind with the CD4 receptor on the membrane of the host cell. This binding causes conformational changes in gp120 that expose coreceptor binding sites (left panel). These sites bind to coreceptor CCR5 or CXCR4 on the membrane of the host cell (center panel), an event that initiates steps that culminate in the fusion of the HIV envelope with the host cell membrane and entry of viral contents into the host cell (inset). Maraviroc binds to and changes the shape of coreceptor CCR5 such that it is not recognized by the gp120 coreceptor binding sites (right panel). Illustration by Taina Litwak, CMI.

希望這樣妳可以了解

CCR的全名？C-C Chemokine Receptor 

做什麼的？

趨化素(Chemokine)是由chemoattractant的字首加上cytokine的字尾而形成的，其主要功能是將白血球吸引到組織受傷處，使白血發揮抵抗病原菌，吞噬病原菌以及啟動免疫反應和發炎反應。趨化素的受器(Chemokine receptor)是屬於seven transmembrane domain G-protein coupled receptor。愈來愈多的研究顯示，趨化素及其受器的功能除了在引導白血球到受傷組織處外，還擔負許多重要的生理功能，例如維持淋巴器官及細胞的恆定性，更重要的是某些趨化素受器被發現是HIV的co-receptor。

另外一個跟CCR5有關的藥物是Trofile

可以參考他網站的介紹：http://www.trofileassay.com/cccr5_antagonist_trofile