The FDA approved class labeling changes for azithromycin tablets and oral suspension to advise of a potential drug interaction with warfarin. On February 27, the label for Zithromax (Pfizer, Inc) was updated.
Although data from a pharmacokinetic study of 22 healthy men taking a 5-day course of azithromycin did not support an interaction with subsequently administered warfarin, postmarketing reports suggest that azithromycin may potentiate the effects of oral anticoagulants.
The FDA advises careful monitoring of prothrombin time in warfarin-treated patients receiving a course of azithromycin.
↑重點就是上面這句話啦↑
Azithromycin is a macrolide antibiotic indicated for the treatment of nongonococcal urethritis and cervicitis as a result of Chlamydia trachomatis and for the prophylaxis and treatment of disseminated Mycobacterium aviumcomplex disease.
Warfarin is an oral anticoagulant indicated for the prophylaxis and/or treatment of venous thromboembolism and pulmonary embolism and for thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement and to reduce the risk for death, recurrent myocardial infarction, and thromboembolic events after myocardial infarction.
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