資料來源：www.nejm.org September 23, 2009
After the diagnosis of novel H1N1 influenza, a 6-year old received a prescription for Tamiflu (oseltamivir) oral suspension (12 mg per milliliter) at a dose of 3/4 teaspoon PO BID.
However, the parents, one a primary care physician and the other one of the authors, had great difficulty determining the correct dose to administer to their child. The medication bottle was accompanied by a prepackaged syringe with markings of 30, 45, and 60 mg .
The label attached by the pharmacy specified the dose in volume units ("3/4 teaspoonful") but the syringe provided only markings in mass units (milligrams).
Despite the disparate directions, the parents were eventually able to determine the correct dose with the aid of 1 of 10 tables in the portion of the package insert intended for prescribers, not for parents.
Specifically, they solved the following equation for the milligram equivalent of the 3/4-tsp dose: 5 ml (volume of a teaspoon)x0.75x12 mg per milliliter Tamiflu suspension=45 mg on the syringe.
總之，那種茶匙的舊時代單位，舊不要再用了，準度超低
以下附上FDA的表格整理：
Dose of Tamiflu for Oral Suspension (12 mg/mL) for Treatment of Influenza
in Pediatric Patients 1 Year or Older by Weight
|
Body Weight (kg) |
Body Weight (lbs) |
Recommended Dose |
Dose (mL) |
Number of Bottles of Tamiflu needed to Obtain the Recommended Doses for a 5 Day Regimen |
|
< 15 kg |
< 33 lbs |
30 mg twice daily |
2.5 mL |
1 |
|
>15 kg to 23 kg |
>33 lbs to 51 lbs |
45 mg twice daily |
3.8 mL |
2 |
|
>23 kg to 40 kg |
>51 lbs to 88 lbs |
60 mg twice daily |
5.0 mL |
2 |
|
>40 kg |
>88 lbs |
75 mg twice daily |
6.2 mL |
3 |
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