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aminolevulinic acid（Levulan® Kerastick®）

Photosensitizing Agent, Topical 光敏感劑，而且只限外用

用法：Actinic keratoses（光化性角化病）: Topical: Apply to actinic keratoses (not perilesional skin) followed 14-18 hours later by blue light illumination. Application/treatment may be repeated at a treatment site (once) after 8 weeks.

用於臉部或是頭部非角化過度的角化病，併用BLU-U藍光照射器來治療，

每次塗抹約354mg，在Kerastick系統中使用，14-18小時候用藍光照射。

這邊有影片介紹：

原理圖解：

粉末配製法：

Levulan® Kerastick®: 20% (1s, 6s) [2-component system containing aminolevulinic acid hydrochloride 354 mg (powder) and diluent containing ethanol 48% (1.5 mL) packaged together in an applicator tube]

未核准用法：

Photodynamic treatment of low-risk superficial basal cell skin cancer and low-risk squamous cell skin cancer in situ (Bowen’s disease)

機轉：

Aminolevulinic acid is a metabolic precursor of the photosensitizer protoporphyrin IX (PpIX). Photosensitization following local application of aminolevulinic acid occurs through the metabolic conversion to PpIX. When exposed to light of appropriate wavelength and energy, accumulated PpIX produces a photodynamic reaction resulting in local cytotoxicity. Precancerous and cancerous cells exhibit a higher rate of porphyrin induction compared to normal cells.