快樂小藥師 Im pharmacist nichts glücklich

Campral（Acamprosate Ca）

目前作用在 

Alcohol abstinence maintainance（戒酒維持療法）

劑量：

 666mg/dase，一天三次，腎功能不好（ccr<50）的人，改成333mg，CCr<30就別用了

也可以依據病患體重調整，A lower dose (4 tablets/day) may be considered in patients with low body weight (eg, <60 kg).

看看長相吧：

副作用那些的，這邊就不寫了

不過要注意每一個錠劑裡面含有33mg的元素鈣

機轉： 

Mechanism not fully defined. Structurally similar to gamma-amino butyric acid (GABA), acamprosate appears to increase the activity of the GABA-ergic system, and decreases activity of glutamate within the CNS, including a decrease in activity at N-methyl D-aspartate (NMDA) receptors; may also affect CNS calcium channels. Restores balance to GABA and glutamate activities which appear to be disrupted in alcohol dependence. During therapeutic use, reduces alcohol intake, but does not cause a disulfiram-like reaction following alcohol ingestion.

與酒精及食物併用時：

Ethanol: Abstinence is required during treatment. Ethanol does not affect the pharmacokinetics of acamprosate; however, the continued use of ethanol will decrease desired efficacy of acamprosate.

Food: Food decreases absorption of acamprosate (not clinically significant).簡單的說，就是不用擔心食物的影響，飯前飯後都無所謂。

特別注意一點，這個藥物並不會減少或是消除酒精戒斷的症狀，如果你想多了解一點酒精戒斷症狀，可以參考這邊：http://mulicia.pixnet.net/blog/post/23855777

另外仿單有提到，如果復發時，還是要繼續吃藥，並儘快與妳的醫師聯絡，當然，服藥期間是不可以喝酒的。

最後，本藥可以磨粉也可以剝半。