Macugen®(Pegaptanib),光看商品名,大概就可以猜出功能了。
外觀:
這邊有仿單資料:http://www.macugen.com/macugenUSPI.pdf
用途:
Treatment of neovascular (wet) age-related macular degeneration (AMD)
治療與年齡有關的血管新生性黃斑部病變
劑量:
Intravitreous injection: 0.3 mg into affected eye every 6 weeks
給藥方式:
直接眼內注射:
機轉:
Pegaptanib
is an apatamer, an oligonucleotide covalently bound to polyethylene
glycol, which can adopt a three-dimensional shape and bind to vascular
endothelial growth factor (VEGF). Pegaptanib binds to extracellular
VEGF, inhibiting VEGF from binding to its receptors and thereby
suppressing neovascularization and slowing vision loss.