Macugen®(Pegaptanib),光看商品名,大概就可以猜出功能了。


外觀:

macugen syringe.JPG 

這邊有仿單資料:http://www.macugen.com/macugenUSPI.pdf

用途:

Treatment of neovascular (wet) age-related macular degeneration (AMD)

 

治療與年齡有關的血管新生性黃斑部病變

劑量:

Intravitreous injection: 0.3 mg into affected eye every 6 weeks

給藥方式:

直接眼內注射:

pegaptanib.jpg 

Macugen.jpg 

機轉:

Pegaptanib is an apatamer, an oligonucleotide covalently bound to polyethylene glycol, which can adopt a three-dimensional shape and bind to vascular endothelial growth factor (VEGF). Pegaptanib binds to extracellular VEGF, inhibiting VEGF from binding to its receptors and thereby suppressing neovascularization and slowing vision loss.



 

 

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