An obese 50-year-old man with no known medical history presented with a necrotizing infection of his right foot that had begun 10 days previously with lesions that he attributed to wearing new shoes. He was found to have diabetes (glycated hemoglobin level, 10.5%) with peripheral neuropathy;

he was afebrile, without leukocytosis or radiographic evidence of bone involvement in his right foot.

The patient had photographed the lesion twice daily, thinking it would heal spontaneously (Panel A).

The preoperative photographs show erythema (day 1), blisters (day 3), a necrotizing abscess (day 6), and wound infection requiring surgery (day 10).

The patient underwent operative débridement; tissue cultures grew Enterobacter cloacae and Streptococcus agalactiae. He was treated with antibiotic agents for 3 weeks.

The infection resolved, with no recurrence or sequelae during 3 years of follow-up (Panel B); during this period, the infection-related swelling disappeared and the patient lost a considerable amount of weight. Diabetic foot infection may evolve rapidly, especially in patients with neuropathy.

螢幕快照 2013-12-07 上午8.18.13.png  


Mickaël Tobalem, M.D., and Ilker Uçkay, M.D.


N Engl J Med 2013; 369:2252December 5, 2013DOI: 10.1056/NEJMicm1211053


    快樂小藥師 發表在 痞客邦 留言(0) 人氣()