Toxic Exposure |
Human Beings |
Dogs |
Cats |
Birds |
Treatment |
Ethylene glycol (antifreeze) |
Intoxication/ CNS depression, metabolic acidosis, oxalate crystals in urine, respiratory/ cardiac difficulty, renal failure, cerebral edema |
(LD 4.4 cc/kg) 30 min-12 hr after ingestion: polyuria, polydipsia, CNS depression, ataxia, vomiting, oxalate crystals in urine 36-72 hr after ingestion: oliguria, lethargy, coma |
(LD 1.4 cc/kg) 30 min-12 hr after ingestion: CNS depression, ataxia, vomiting, polyuria, oxalate crystals in urine 12–24 hr after injection: oliguria, lethargy, coma, swollen/ painful kidneys |
(poultry LD 7-8 cc/kg)23 CNS depression, ataxia |
Fluids, supportive care In human beings and dogs, fomepizole to inhibit ADH In cats, ethanol to inhibit ADH Dialysis effective for renal insufficiency in human beings |
Household cleaners Chlorine bleach, ammonia, others |
nhalation: respiratory irritation (fumes): coughing, gagging, sneezing, asthma Ingestion: GI distress, vomiting Dermal: skin irritation |
Ingestion: vomiting, hypersalivation, depression Inhalation: coughing, gagging, sneezing |
Pulmonary irritation, retching, coughing Concentrated ammonia: seizures and death within 5 minutes |
Respiratory irritation, death |
Removal from exposure, substitution of less irritating cleaning agents, supportive care of irritation |
Slug bait (metaldehyde)
|
Toxic level not known; most ingestions not serious Salivation, nausea, vomiting, abdominal pain, tachycardia can occur |
Immediate to 3 hr after ingestion: Convulsions, tremors, hyperthermia, hyperpnea, vomiting, cyanosis, depression, ataxia, seizures, death LD50 (ingestion) 100 mg/kg in dogs, 207 mg/kg cats11 |
LD50 500 mg/kg (chickens) |
Remove from GI tract, activated charcoal; control seizures, spasms; treat acidosis |
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Plants |
Many plants with low toxicity |
Many plants toxic to animals, including lilies, azaleas, rhododendron |
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Oleander (cardiac glycosides) |
Dizziness, nausea, cardiac arrhythmias |
Vomiting, diarrhea, cardiac toxicity (tachycardia, heart block) |
GI decontamination, activated charcoal Cardiac monitoring, digoxin-specific Fab fragment |
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Mushrooms, toadstools (Amanita toxin
|
Amanita: Liver, kidney toxicity: vomiting, pain, jaundice
|
GI decontamination, activated charcoal
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Rodenticides |
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Warfarin and related compounds |
Bleeding |
Anemia, spontaneous bleeding, hematomas, melena |
GI decontamination, charcoal, vitamin K |
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Bromethalin |
Altered mental status, seizures |
Hindlimb ataxia, tremors, hyperthermia, seizures, coma |
GI decontamination, treatment of cerebral edema |
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Teflon fumes (PFOA)
|
Polymer fume fever (flulike symptoms) |
None known
|
Respiratory distress, death |
Remove from exposure, supportive care |
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