[期刊轉載]American Gastroenterological Association medical position statement on constipation.
[Medscape][FDA Approvals]FDA Approves Amitiza for Opioid-induced Constipation
Category |
Subcategory |
Examples |
Dietary andlifestyle |
Dehydration or inadequate fluid intake Low fiber diet Bed rest or inactivity |
Chronic suppression of defecatory urge |
Medications |
Analgesics |
Opioids, nonsteroidal anti-inflammatories |
|
Diuretics |
Thiazide diuretics, loop diuretics |
|
Antihypertensives |
Calcium channel blockers, clonidine |
|
Anticholinergics |
Antihistamines, antispasmodics, antidepressants,antipsychotics |
|
Bile acid resins |
|
|
Cation-containing agents |
Barium, iron supplements, calcium or aluminum (dietary supplements, antacids, sucralfate) |
|
Neurally active agents |
Ganglionic blockers, serotonin antagonists,vinca alkaloids |
Structural |
Anorectal |
Rectal prolapse,rectal intussusception,rectocele, anorectal stricture, perineal descent, anal sphincter spasm from anal fissure or painful hemorrhoids, solitary rectal ulcer,megarectum,neoplasm,fecal impaction |
|
Colonic stricture or obstruction |
Neoplasm, ischemia, inflammation (diverticulitis, proctitis), post-radiation |
Neurogenic |
Peripheral neurologic dysfunction |
Autonomic neuropathy, diabetes mellitus, Hirschsprung’s disease, American trypanosomiasis |
|
Central neurologic dysfunction |
Multiple sclerosis, Parkinson disease, spinal cord injury or tumor,cerebrovascular accident
|
|
Colonic pseudoobstruction |
Megacolon, Ogilvie syndrome |
|
Cerebral impairment leading to defecatory failure |
Dementia, traumatic brain injury, stroke |
Other systemic |
Endocrine |
Hypothyroidism, diabetes mellitus, hyperpara- thyroidism, panhypopituitarism, pheochro- mocytoma, pregnancy |
|
Metabolic |
Chronic kidney disease, electrolyte abnormalities (hypercalcemia, hypokalemia, hypomagnese- mia), heavy metal poisoning, porphyria |
|
Myopathic |
Myotonic dystrophy, scleroderma, amyloidosis |
|
Psychiatric |
Depression, anorexia nervosa, dementia, abuse |
|
Other |
Sarcoidosis |
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