小藥師最近整理一系列有關類固醇的表格及資料,提供給大家做參考

關於類固醇的文章收集

 
Drug
Route
T1/2
Onset
Peak
Duration
Hydrocortisone
P.O.
Plasma: 1.5–2
Tissue: 8–12
 
1 hr
1.25–1.5 days
IM
 
 
4–8 hr
 
Hydrocortisone Sodium succinate(solu-cortef)
IV
 
Rapid30~50min
 
variable
IM
 
 
1 hr
 
Methylprednisolone
PO
 
 
1–2 hr
1.25–1.5 days
Methylprednisolone Sodium succinate
(solu-medrol)
IV
 
 
 
 
IM
Plasma:>3.5hr
Tissue: 18–36
6~48hr
4~8day
1~4week
Betamethasone Sodium phosphate
(rinderone)
IM
3–5 hr
1–3 hr
 
1 wk
IA, IS
 
 
 
1~2 wk
IL, ST
 
 
 
1 wk
Dexamethasone Sodium phosphate
IV
3–4.5hr
Rapid
 
 
IM
 
Rapid
 
 
IA, IS, IL, ST
 
 
 
3 days–3 wk
IA = intra-articular; IB = intrabursal; IL = intralesional; IM = intramuscular; IS = intrasynovial; ST = soft tissue.
    Solu-cortef: protein binding is Very high.
    Dexamethasone: protein binding is high.
    Betamethasone: protein binding is high.
 
若以hydrocortisone效價為”1”
Drug
Activity
hydrocortisone
1
Prednisolone
4
Methylprednisolone
5
dexamethasone
20~30
Betamethasone
20~30
 
 另外提供換算機給大家參考:http://www.medcalc.com/steroid.html

 

    快樂小藥師 發表在 痞客邦 留言(3) 人氣()