小藥師最近整理一系列有關類固醇的表格及資料，提供給大家做參考
關於類固醇的文章收集
|
Drug
|
Route
|
T1/2
|
Onset
|
Peak
|
Duration
|
|
Hydrocortisone
|
P.O.
|
Plasma: 1.5–2
Tissue: 8–12
|
|
1 hr
|
1.25–1.5 days
|
|
IM
|
|
|
4–8 hr
|
|
|
|
Hydrocortisone Sodium succinate(solu-cortef)
|
IV
|
|
Rapid30~50min
|
|
variable
|
|
IM
|
|
|
1 hr
|
|
|
|
Methylprednisolone
|
PO
|
|
|
1–2 hr
|
1.25–1.5 days
|
|
Methylprednisolone Sodium succinate
(solu-medrol)
|
IV
|
|
|
|
|
|
IM
|
Plasma:>3.5hr
Tissue: 18–36
|
6~48hr
|
4~8day
|
1~4week
|
|
|
Betamethasone Sodium phosphate
(rinderone)
|
IM
|
3–5 hr
|
1–3 hr
|
|
1 wk
|
|
IA, IS
|
|
|
|
1~2 wk
|
|
|
IL, ST
|
|
|
|
1 wk
|
|
|
Dexamethasone Sodium phosphate
|
IV
|
3–4.5hr
|
Rapid
|
|
|
|
IM
|
|
Rapid
|
|
|
|
|
IA, IS, IL, ST
|
|
|
|
3 days–3 wk
|
IA = intra-articular; IB = intrabursal; IL = intralesional; IM = intramuscular; IS = intrasynovial; ST = soft tissue.
＊ Solu-cortef: protein binding is Very high.
＊ Dexamethasone: protein binding is high.
＊ Betamethasone: protein binding is high.
若以hydrocortisone效價為”1”
|
Drug
|
Activity
|
|
hydrocortisone
|
1
|
|
Prednisolone
|
4
|
|
Methylprednisolone
|
5
|
|
dexamethasone
|
20~30
|
|
Betamethasone
|
20~30
|
另外提供換算機給大家參考：http://www.medcalc.com/steroid.html
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