快樂小藥師 Im pharmacist nichts glücklich

DRUG

GROUP

ASPIRATE

And instill

steroids⁰⁰¹

'SPREAD' AND DILUTE

LOCALISE AND NEUTRALISE

SPECIFIC MANAGEMENT

ADDITIONAL

INFORMATION

Doxorubicin Liposomal

4

Y

Y

Apply topical hydrocortisone and cover the area with an ice pack for up to 12 hours, h then at 8-12 hours post incidence apply DMSO 2 hourly for the next 24 hours.3

Avoid contact with good skin. If blistering occurs, stop the DMSO and seek further advice

Epirubicin

5

Y

Y

Apply topical DMSO, every 2 hours at the extravasation site followed by topical hydrocortisone and a cold compress.1 h

Avoid contact with good skin. If blistering occurs, stop the DMSO and seek further advice. Sodium bicarbonate may have a role. Surgical excision e is sometimes required to prevent serious damage

Etoposide

3

Y

Y

Apply topical hydrocortisone and cover the area with an ice pack. 2 h

Possibility of local inflammation or necrosis and/or pain . There are no specific antidotes.

Etoposide Phosphate

2

Y

Y

Apply topical hydrocortisone and cover the area with an ice pack h for the next 4 hours. If the local reaction has then settled apply heat g for a further 24 to 48 hours. 2

Possibility of local inflammation. S/C hyaluronidase may facilitate dispersion of large volume extravasations in addition to the warm compressions

Floxuridine

4

Y

Y

Infiltrate with sodium bicarbonate c into the area, followed by heat (i.e. warm compress g)

Extravasation is rare.

See j

Fludarabine

1

Y

Y

Infiltrate the site with hyaluronidase.a Apply heat and compression.2 g