這個藥物其實之前介紹過:
[US pharmacist]New Drug Review 2012 新藥回顧
結構:
不過這邊把一些收集到的機轉圖給各位參考:
機轉:
Abiraterone acetate is metabolized to abiraterone, an androgen biosynthesis inhibitor of CYP17 which decreases androgen levels and deprives androgen-sensitive prostatic carcinomas. It accomplishes this by interfering with the CYP17-catalyzed reactions involved in the production of dehydroepiandrosterone (DHEA) and androstenedione. Inhibition of CYP17 can result in increased mineralocorticoid production by the adrenals
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