新增了MTP機轉還有新的藥物
Lomitapide (Juxtapid®)是與低脂肪膳食及其他方法配合使用,可減少壞膽固醇的含量,但由於可能對患者的肝臟構成損害,故Juxtapid的供應將受到限制。
機轉:Lomitapide mesylate is a synthetic lipid-lowering agent that binds to and inhibits microsomal triglyceride transfer protein (MTP), which prevents the assembly of apo B-containing lipoproteins in hepatocytes and enterocytes. Therefore, the synthesis of chylomicrons and VLDL is inhibited, which leads to reduced levels of LDL-C
結構:
文章標籤
全站熱搜
留言列表