快樂小藥師 Im pharmacist nichts glücklich

最新研究發現，晚上以及清晨發生急性痛風的機率，比白天時多了將近一倍。Dehydration, lower body temp, or hormonal shifts may be to blame, expert says
　　
　　麻州綜合醫院/哈佛醫學院的Hyon Choi博士在期刊新聞稿指出，他們推測，體溫較低、晚上脫水、或是皮質醇含量夜間下降造成晚上痛風發作的風險。
　　
　　研究人員發現，甚至那些在痛風發作前24小時攝取很少普林的患者，風險也會增加。當無法處理普林時，身體就會產生尿酸。急性痛風發作就是因為關節中的尿酸結晶化而誘發。普林含量較高的食物包括臟器、海鮮、以及酒類。
　　
　　資料來源：http://www.24drs.com/WebMD/chinese_t.asp?page=1&who=091e9c5e8107d9fd

Acute gout attacks occur two times more often during the night and early morning than during the day, a new study finds.

"It is speculated that lower body temperature, nighttime dehydration, or a nocturnal dip of cortisol levels may contribute to the risk of goutattacks at night," study author Dr. Hyon Choi, of Massachusetts General Hospital/Harvard Medical School, said in a journal news release.

"Despite the possibility of a nighttime link to gout, no study prior to our current investigation has looked at the association between gout attack risk and the time of day," Choi added.

More than 8 million Americans have gout, according to the American College of Rheumatology.

The current study included more than 700 gout patients. Their average age was 54. They were mostly white, and mostly male, according to the study.

The researchers tracked their health for one year. During that time, there were almost 1,500 acute gout attacks.

Of those, more than 700 occurred between midnight and 7:59 a.m. Around 300 happened between 8 a.m. and 2:59 p.m. And, almost 400 attacks occurred between 3 p.m. and 11:59 p.m., according to the findings in the journal Arthritis & Rheumatology.

Compared to daytime, the risk of an acute gout attack was more than twice as high overnight.

The increased risk was seen even among patients with low purine intake in the 24 hours prior to an attack, the researchers found. When breaking down purines, the body produces uric acid. Acute gout attacks are triggered by the crystallization of uric acid within joints. Certain foods are high in purines, including organ meat, seafood and alcohol.

"Our findings provide the first prospective evidence that the risk of gout flares is higher during the night and early morning hours than during the day," Choi concluded. "As a result of our study, [preventive] measures that prevent gout flares, especially at night, may be more effective."