快樂小藥師 Im pharmacist nichts glücklich

Dantrolene由於保存不易加上藥品昂貴，所以不是每一家醫院的常備藥

幸好現在已經有台灣麻醉醫學會幫忙建立庫存檔案，所以你只要前往該網站：

http://www.anesth.org.tw

或是直接點擊這個連結：

http://www.anesth.org.tw/quality_safety/dantrolene.asp

就可以得知最近的庫存資訊

圖解如下：

進入台灣麻醉醫學會

選擇品質與安全

選擇Dantrolene庫存

這樣就可以了

補充一點資料：

Adult Dosing .

Dosage forms:  25,50,100

spasticity, chronic

[100 mg PO tid-qid]

Start: 25 mg PO qd x7 days, then 25 mg PO tid x7 days, then 50 mg PO tid x7 days, then 100 mg PO tid; Max: 100 mg PO qid; Info: use lowest effective dose; D/C if no response after 45 days

Mechanism of Action

dissociates excitation-contraction coupling in skeletal muscle by decreasing intracellular calcium, inducing skeletal muscle relaxation

Black Box Warnings .

Hepatotoxicity

use only for recommended conditions at lowest effective dose; D/C tx if no observed benefit after 45 days; frequently monitor hepatic fxn incl. AST/ALT; fatal and non-fatal symptomatic hepatitis reported at various dose levels; lower incidence w/ 400 mg/day compared to >800 mg/day; sporadic short courses >800 mg/day w/in tx regimen markedly incr. risk; elev. LFTs reported w/ various lengths of exposure; hepatitis occurred at varying intervals after tx start, but most frequently between 3rd-12th mo of tx; incr. risk in female pts, pts >35 yo, and w/ concomitant meds; possible higher incidence of fatal outcome in elderly pts, but cases complicated by confounding factors incl. intercurrent illnesses and/or concomitant hepatotoxic meds