Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents


Ethanol (78-95%), 2-propanol (70-100%), the combination of 45% 2-propanol with 30% 1-propanol, glutardialdehyde (0.5-2.5%), formaldehyde (0.7-1%) and povidone iodine (0.23-7.5%) readily inactivated coronavirus infectivity by approximately 4 log10 or more. (Table 2). Sodium hypochlorite required a minimal concentration of at least 0.21% to be effective. Hydrogen peroxide was effective with a concentration of 0.5% and an incubation time of 1 min. Data obtained with benzalkonium chloride at reasonable contact times were conflicting. Within 10 min a concentration of 0.2% revealed no efficacy against coronavirus whereas a concentration of 0.05% was quite effective. 0.02% chlorhexidine digluconate was basically ineffective (Table II).。

Inactivation of coronaviruses by biocidal agents in carrier tests

Ethanol at concentrations between 62% and 71% reduced coronavirus infectivity within 1 min exposure time by 3.0–4.0 log10. Concentrations of 0.1- 0.5% sodium hypochlorite and 2% glutardialdehyde were also quite effective with > 3.0 log10 reduction in viral titre. In contrast, 0.04% benzalkonium chloride, 0.06% sodium hypochlorite and 0.55% ortho-phtalaldehyde were less effective (Table III).







    快樂小藥師 發表在 痞客邦 留言(0) 人氣()