資料來源：MIMs 2007
降血脂藥適應症比較
|
藥理分類及機轉
|
作用位置
|
藥物
|
高血脂分期
|
同型接合子家族性高膽固醇血症
|
||||||
|
LDL-C
|
HDL-C
|
TG
|
Ⅱa
|
Ⅱb
|
Ⅲ
|
Ⅳ
|
Ⅴ
|
|||
|
降低LDL藥物
|
||||||||||
|
Statins
HMG-CoA RI |
↓18-63%
|
↑5-15%
|
↓7-30%
|
Atorvastatin
|
✓
|
✓
|
✓
|
✓
|
|
✓
|
|
Fluvastatin
|
✓
|
✓
|
|
|
|
|
||||
|
Lovastatin
|
✓
|
✓
|
|
|
|
|
||||
|
Pravastatin
|
✓
|
✓
|
✓
|
✓
|
|
✓
|
||||
|
Rosuvastatin
|
✓
|
✓
|
|
✓
|
|
✓
|
||||
|
Simvastatin
|
✓
|
✓
|
|
|
|
|
||||
|
Bile acid sequestrant
|
↓15-30%
|
↑3-5%
|
↑20-30%
|
Cholestyramine
|
✓
|
|
|
|
|
|
|
Cloestipol
|
✓
|
|
|
|
|
|
||||
|
Colesevelam
|
✓
|
|
|
|
|
|
||||
|
選擇性吸收抑制劑
|
↓18-21%
|
↑2%
|
↓4-11%
|
Ezetimibe
|
✓
|
|
|
|
|
✓
|
|
調整TG及HDL藥物
|
||||||||||
|
Fibrate
|
如果高膽固醇，TG正常：↓5-20%
如果膽固醇及TG均高：↓10-25%
|
↑10-20%
|
↓20-50%
|
bezafibrate
|
✓
|
✓
|
✓
|
✓
|
✓
|
|
|
Ciprofibrate
|
✓
|
✓
|
|
✓
|
|
|
||||
|
Clofibrate
|
✓
|
|
|
✓
|
|
|
||||
|
Etofibrate
|
|
✓
|
|
|
|
|
||||
|
Fenofibrate
|
✓
|
✓
|
✓
|
✓
|
✓
|
|
||||
|
Gemfibrozil
|
✓
|
✓
|
✓
|
✓
|
✓
|
|
||||
|
Nicotinic acid
|
|
↑15-35%
|
↓20-50%
|
Acipimox
|
✓
|
✓
|
✓
|
✓
|
✓
|
|
|
Niceritrol
|
✓
|
|
|
|
|
|
||||
|
Nicomol
|
✓
|
|
|
|
|
|
||||
|
Niacin
|
✓
|
✓
|
|
|
|
|
||||
TypeⅡa=primary hypercholesterolemia includes heterozygous familial and non familial（↑LDL only）
TypeⅡb=combined hyperlipidemia or mixed dyslipidemia
TypeⅢ=broad beta disease;dysbetalipoproteinemia
TypeⅣ=endogenous hypertriglyceridemia;hyperprebetalipoproteinemia
TypeⅤ=Mixed hypertriglyceridemia;mixed hyperlipidemia; hyperprebetalipoproteinemia with chylomicronemia
全站熱搜
留言列表
醫藥類 (14)
