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Gonorrhea may soon reach superbug status thanks to growing antibiotic resistance to the common sexually transmitted infection.

March 29, 2010 -- Gonorrhea may soon reach superbug status, thanks to growing antibiotic resistance to the common sexually transmitted infection.

A new study shows that treating gonorrhea is becoming more difficult because the bacterium has become resistant to many antibiotics. If trends continue, researchers say there is a very real possibility that some strains of Neisseria gonorrhoeae may become resistant to all current treatment options.

Gonorrhea is a common sexually transmitted bacterial infection. If left untreated, gonorrhea can lead to pelvic inflammatory disease , ectopic pregnancy , and infertility in women. Treatment for gonorrhea usually consists of a single dose of one of two antibiotics, cefixime or ceftriaxone.

"Choosing an effective antibiotic can be a challenge because the organism that causes gonorrhea is very versatile and develops resistance to antibiotics very quickly," researcher Catherine Ison, professor at the Health Protection Agency Centre for Infections in London, says in a news release. "Penicillin was used for many years until it was no longer effective and a number of other agents have been used since.”

Ison presented a report on the growing antibiotic resistance of gonorrhea at the Society for General Microbiology Spring Meeting this week in Edinburgh, Scotland. She says the bacterium that causes gonorrhea is highly versatile and adept at acquiring and developing resistance to antibiotics.

“The current drugs of choice, ceftriaxone and cefixime, are still very effective but there are signs that resistance, particularly to cefixime, is emerging and soon these drugs may not be a good choice," Ison says.

"There are few new drugs available and so it is probable that the current use of a single dose may soon need to be revised and treatment over several days or with more than one antibiotic will need to be considered," Ison says. "If this problem isn't addressed then there is a real possibility that gonorrhea will become a very difficult infection to treat."

WebMD Health News 
by Jennifer Warner 
Reviewed By Laura Martin

Last Modified: 2010/3/29 下午 07:04:45

c 2010 WebMD, LLC. All rights reserved.

 中文翻譯在這邊：

【24drs.com】March 29, 2010 -- 淋病可能很快就會達到超級細菌的狀態，這要歸功於常見的性病感染有越來越多抗生素抗藥性。
　　
　　最新研究顯示，治療淋病變得越來越困難了，因為這種細菌變得對許多抗生素都有抗藥性。研究人員表示，如果趨勢是如此的話，淋病雙球菌（Neisseria gonorrhoeae）就非常有可能變成對目前所有的治療用藥都有抗性。
　　
　　淋病是一種常經由性行為傳播的細菌感染，如果沒有及時治療的話，可能導致婦女骨盆腔發炎、子宮外孕、或是不孕。淋病治療通常是使用一劑或兩劑抗生素，cefixime以及ceftriaxone。
　　
　　倫敦健康保護局感染中心的研究員Catherine Ison在新聞稿中表示，很難選出有效的抗生素，因為會導致淋病的有機體反覆無常，而且很快就會產生抗生素抗藥性。青黴素使用了很多年，用到它不再有效為止，還有許多其他藥品被使用至今。
　　
　　Ison在蘇格蘭愛丁堡舉辦的普通微生物學會春季會議中發表的報告顯示，有越來越多淋病的抗生素抗藥性，她表示，會導致淋病的細菌是非常多變的，很容易得且容易有抗生素抗藥性。
　　
　　Ison表示，目前選擇的藥物ceftriaxone與cefixime仍然十分有效，但有跡象顯示有抗藥性，特別是cefixime已經浮現這個問題，這些藥物很快地會變成不是一個很好的選擇。
　　
　　Ison表示，目前很少有新的藥物可以使用，因此，目前使用的單一藥劑可能很快就需要修正，而且需要考慮是要治療幾天還是要使用一種以上的抗生素。如果這個問題不解決，淋病可能將成為一個非常難治療的感染疾病。 

另外，你也可以參考這一篇：Ceftriaxone and Syphilis