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Drugs with a Risk of Torsades de Pointes 會引起Torsades de Pointes風險的藥物

Drugs with a Possible Risk of Torsades de Pointes 可能引起Torsades de Pointes的藥物

 資料來源:http://www.azcert.org/medical-pros/drug-lists/drug-lists.cfm

 

Generic Name

Brand Name

 

Class/Clinical Use

Comments

Amantadine

Symmetrel®

Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease

 

Amisulpride

Solian® and others

Antipsychotic, atypical /

Risk of TdP  with overdose - not available in US

Amitriptyline

Elavil® (Discontinued 6/13)

Tricyclic Antidepressant / depression

Risk of TdP with overdosage

Chloral hydrate

Noctec®

Sedative / sedation/ insomnia

 

Ciprofloxacin

Cipro®

Antibiotic / bacterial infection

Drug interaction risk - metabolic inhibitor

Clomipramine

Anafranil®

Tricyclic Antidepressant / depression

 

Desipramine

Pertofrane®

Tricyclic Antidepressant / depression

Risk of TdP with overdosage

Diphenhydramine

Benadryl®

Antihistamine / Allergic rhinitis, insomnia

Risk of QT increase/TdP in overdosages

Diphenhydramine

Nytol®

Antihistamine / Allergic rhinitis, insomnia

Risk of QT increase/TdP in overdosages

Doxepin

Sinequan®

Tricyclic Antidepressant / depression

 

Fluconazole

Diflucan®

Anti-fungal / fungal infection

Drug interaction risk- metabolic inhibitor. Can also increase QT at high doses - 800 mg/day

Fluoxetine

Sarafem®

Anti-depressant / depression

 

Fluoxetine

Prozac®

Anti-depressant / depression

 

Galantamine

Reminyl®

Cholinesterase inhibitor / Dementia, Alzheimer's

 

Imipramine

Norfranil®

Tricyclic Antidepressant / depression

TdP risk with excess dosage

Itraconazole

Sporanox®

Anti-fungal / fungal infection

Drug interaction risk - metabolic inhibitor

Ketoconazole

Nizoral®

Anti-fungal / fungal infection

Prolongs QT & Drug interaction risk - metabolic inhibitor.

Nortriptyline

Pamelor®

Tricyclic Antidepressant / depression

 

Paroxetine

Paxil®

Anti-depressant / depression

 

Protriptyline

Vivactil®

Tricyclic Antidepressant / depression

 

Quinine sulfate

Qualaquin®

Anti-malarial / Malaria or leg cramps

TdP with overdose or drug-drug or drug food interaction

Ritonavir

Norvir®

Protease inhibitor / HIV

 

Sertraline

Zoloft®

Anti-depressant / depression

 

Solifenacin

VESIcare®

muscarinic receptor anatagonist / treatment of overactive bladder

 

Trazodone

Desyrel® (brand discontinued 6/13)

Anti-depressant / Depression, insomnia

 

Trimethoprim-Sulfa

Septra® or Bactrim®

Antibiotic / bacterial infection

Also available in DS (double strength)

Trimipramine

Surmontil®

Tricyclic Antidepressant / depression

 

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